It is important to understand What proteins are capable of sensing cellular stress? How are they altered in metabolic disease? Can these metabolic checkpoints be targeted in metabolic disease?

Who is next? If you are interested in the cellular energy metabolism, please contact to Haejin Yoon   (haejinyoon@units.ac.kr)!

Yoon lab's overall research motivation is to develop new therapeutic strategies to treat metabolic diseases. Traditionally, personalized medicine uses genetic characteristics and biomarkers of a disease to develop metabolic disease treatments, as in the case of cancer. Through my research, we suggest metabolite and nutrition can be used as the basis for the development of new treatments for metabolic diseases.

These will be new biomarkers, and will mean finding new metabolic pathways and novel strategies for treatment. This new way to combat metabolic disease using metabolites and nutrients will be relatively stable and reduced side effects. This work will not in only assay development it will also help improve human life and health .

Aberrant mitochondrial structure in muscle disease model.

PHD3 regulation of fat metabolism. Heat map depicting metabolite abundance in PHD3 knockdown, AMPKα knockout or non-silencing control MEFs. Volcano plots demonstrating that PHD3 and AMPK depleted MEFs have numerous statistically significant metabolic changes compared to control cells (Yoon et al., 2020. Cell Metab)

Who is next? If you are interested in the cellular energy metabolism, please contact to Haejin Yoon   (haejinyoon@units.ac.kr)!